Professor Dean Ho, director of the Institute for Digital Medicine (WisDM) at the National University of Singapore’s (NUS) Yong Loo Lin School of Medicine, has reported a significant reduction in his biological age through a self-conducted longevity study dubbed “Delta.” According to the findings published in the peer-reviewed journal PLOS One, the 47-year-old professor achieved a physiological age profile equivalent to a 32-year-old after eight months of intensive lifestyle interventions.
The study, which began in August 2024 and remains ongoing, utilized continuous data collection via three wearable devices—Whoop, Garmin, and an Apple Watch. Prof. Ho implemented a strict regimen including intermittent fasting—often fasting for 20 hours daily with periodic 48-hour sessions—alongside a Mediterranean-style diet and 90 minutes of daily strength or cardio exercise.
Key physiological improvements recorded during the eight-month period included a decrease in metabolic switching speed from over 24 hours to 16.5 hours, and a reduction in resting heart rate from 65 to 46 beats per minute. Additionally, his sleep duration increased from five to nearly eight hours, with a marked improvement in deep sleep quality. The research team utilized a custom artificial intelligence copilot to interpret the aggregated health data.
NUS Medicine has issued a clear caveat regarding the results, emphasizing that the findings reflect Prof. Ho’s individual physiological response. The institution noted that these outcomes are not necessarily replicable by the general public, and the study serves primarily as a pilot to explore the potential of shifting from static annual health screenings to real-time, data-driven physiological monitoring.